Encephalitis identified as rare toxicity of immunotherapy treatment

After a cancer patient receiving an immunotherapy developed encephalitis and died 18 months into treatment, researchers at Vanderbilt-Ingram Cancer Center (VICC) investigated why the complication occurred, performing a molecular analysis of the disease’s pathology and mining data to determine the incidence of similar occurrences. The molecular analysis revealed the presence of T cells known to react to Epstein-Barr virus in […]

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Researchers compare visceral leishmaniasis diagnostic tests

Accurate and timely diagnosis of the tropic disease visceral leishmaniasis (VL) is one of the pillars for reducing VL deaths. Currently available serological tests for diagnosing VL vary widely in their performance and may, as a whole, be inadequate for VL diagnosis, researchers report in PLOS Neglected Tropical Diseases. Visceral leischmanisis is the most severe form of leishmaniasis and is […]

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HIV vaccine nears clinical trial following new findings

A promising vaccine that clears an HIV-like virus from monkeys is closer to human testing after a new, weakened version of the vaccine has been shown to provide similar protection as its original version. A pair of papers published July 17 in Science Translational Medicine describe how the vaccine—which uses a form of the common herpes virus cytomegalovirus, or CMV—was […]

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Biocompound from Atlantic Rainforest combats leishmaniasis and Chagas disease

Natural compounds isolated from Nectandra leucantha, a neotropical tree species belonging to the laurel family (Lauraceae) and endemic to the Atlantic Rainforest biome in Brazil, where its common name is canela-seca or canela-branca, could result in new medications for the treatment of visceral leishmaniasis and Chagas disease. In a study supported by São Paulo Research Foundation—FAPESP, researchers at Adolfo Lutz […]

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Maternal obesity linked to childhood cancer

A new study from the University of Pittsburgh Graduate School of Public Health and UPMC Hillman Cancer Center found that children born to obese mothers were more likely to develop cancer in early childhood. Using Pennsylvania birth records, the researchers found a correlation between pre-pregnancy body-mass index (BMI) in mothers and subsequent cancer diagnosis in their offspring, even after correcting […]

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How the mosquito immune system fights off the malaria parasite

A new study from Iowa State University entomologists describes how mosquitoes fight off parasites that cause malaria, a disease that sickens millions of people every year. The study, published recently in the scientific journal Proceedings of the National Academy of Sciences, shows how the mosquito immune system combats malaria parasites at multiple stages of development. A better understanding of the […]

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Using ‘self-talk’ as part of your endurance sport training? Here’s what you need to know

You have probably caught yourself muttering some encouragement to yourself, perhaps when you were facing a particularly difficult physical challenge, or experiencing some sort of stress; “Come on, you can do this!” or “I know I can do this!” Sports psychologists have now found that speaking to yourself in the second person: “You need to dig deep!”, is actually more […]

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‘Surprising’ lack of progress on heart disease in younger adults

After years of declining rates of coronary artery disease, new research shows the trend is reversing among younger people, especially women. The culprit may be the rise in obesity, diabetes and high blood pressure rates among young adults, according to a study published Monday in the Journal of the American Heart Association. Researchers from the University of British Columbia in […]

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