Could sphingolipids help solve a racial paradox in heart disease?

When it comes to cholesterol, we’ve come to accept a simple narrative. Our risk of heart disease is lower when we have more “good cholesterol,” or high-density lipoproteins (HDL), and less “bad cholesterol,” or low-density lipoproteins (LDL) and triglycerides. Complicating this narrative, however, is the higher risk of severe heart disease in African Americans, despite the fact that they tend […]

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Researchers develop new database of druggable fusion targets

When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play a vital role in the development of cancers and other complex diseases. However, there are very few resources which collate all this […]

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Majority of childhood sex-abuse survivors achieve complete mental health

Most research on child sexual-abuse survivors focuses on negative consequences such as depression and suicide. A new study instead examines factors associated with resilience and flourishing among adult survivors. “Remarkably, two-thirds [65%] of the childhood sexual-abuse survivors in our sample met the criteria for complete mental health—defined as being happy or satisfied with life most days in the past month, […]

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Risk for ischemic CV events lower with colchicine after MI

(HealthDay)—Patients with recent myocardial infarction have a lower risk for ischemic cardiovascular events with colchicine versus placebo, according to a study published online Nov. 16 in the New England Journal of Medicine to coincide with the annual meeting of the American Heart Association, held from Nov. 16 to 18 in Philadelphia. Jean-Claude Tardif, M.D., from the Montreal Heart Institute, and […]

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Standard treatment programmes for OCD are not always enough

They wash their hands until the skin hangs in tatters, are in a state of panic about bacteria and infections—and are unable to use common sense and distance themselves from the stressful thoughts that are controlling their lives. Teenagers with the contamination and washing variant of OCD are not generally more ill than children and adolescents with other forms of […]

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Pakistan becomes first country to launch new typhoid vaccine

Pakistan has become the first country in the world to introduce a new typhoid vaccine, officials said Friday, as the country grapples with an ongoing outbreak of a drug-resistant strain of the potentially fatal disease. The vaccine, approved by the World Health Organization (WHO), will be used during a two-week immunisation campaign in southern Sindh province. Sindh is where most […]

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Treatment to ward off stroke less effective in women

Women are at higher risk for stroke and have different stroke symptoms than men. New research suggests another difference: less benefit from a surgery used to treat carotid artery disease, a key risk factor for stroke. The disease, also called carotid stenosis, is marked by fatty deposits, called plaque, that build up inside the neck arteries and increase stroke risk. […]

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Life experience critical for managing type 2 diabetes

A team of researchers at Carnegie Mellon University found that age plays a critical role in the well-being of people newly diagnosed with Type 2 diabetes, with younger patients more susceptible to psychological distress resulting in worse health outcomes. “We found we can evaluate a patient’s initial stress and predict how they will be doing six months later,” said Vicki […]

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Zika virus can cause immune and brain abnormalities in asymptomatic pig offspring

Zika virus infection in the womb produces altered immune responses and sex-specific brain abnormalities in apparently healthy pig offspring, according to a study published november 14 in the open-access journal PLOS Pathogens by Uladzimir Karniychuk of the University of Saskatchewan, and colleagues. As noted by the authors, the findings could point to new strategies to prevent and alleviate the long-term […]

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New method described for quantifying antisense oligonucleotides in nuclei

A novel method uses subcellular fractionation to quantify label-free antisense oligonucleotides (AONs)- designed to silence targeted genes—that have crossed into the nucleus of a cell, where they can exert their effects. Researchers used this method to correlate nuclear entry of several AON molecules with target gene knockdown and they report their results in Nucleic Acid Therapeutics. Troels Koch and colleagues […]

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