Drugs to reduce cholesterol weaken the muscles and the nervous system

What are the effects statins have on our muscles?

Researchers found now that the so-called Statin-induced drugs that are normally prescribed for people with a high cholesterol, can lead to a weakening of the muscles and of the nervous system Affected.

The scientists of the ETH Zurich established in their current study that treatment with statins weakens in people with high cholesterol level in the muscles and the nervous system of those Affected. The experts published the results of their study in the English journal “Cell Metabolism”.

Statins reduce the formation of brown adipose tissue

According to the current knowledge of medical professionals statins reduce tissue, the formation of brown fat, which usually sugar and fat is converted into heat. The brown adipose tissue helps people to regulate their body temperature in the Winter is better, in addition, these people also suffer less Obesity or Diabetes.

How are the white fat cells to brown fat cells?

The team of researchers dealt with the question of how white fat cells which form the layer of fat under our skin to beneficial brown fat cells. In the execution of cell culture experiments, the experts found that the cholesterol production is responsible biochemical pathway plays a Central role in this transformation. The scientists discovered that the key molecule, which is the transformation of regulated, is the metabolite with the designation of geranyl geranyl pyrophosphate.

What are the effects of statins on brown adipose tissue?

There are also so-called positron-Emission-tomography-Scans at 8,500 patients have been performed. This study noted whether the subjects were in brown adipose tissue. The physicians were also informed about whether the patient statins. The evaluation of the Scans showed that six percent of the patients who had tissue the drug revenue, brown fat. This tissue type was only a little over one percent of the patients, when these statins.

Statins protect against cardiovascular disease

The researchers performed a separate clinical study with 16 persons, in order to show that statins reduce the activity of brown adipose tissue. It must be borne in mind that statins are incredibly important to prevent cardiovascular diseases. Statins save millions of lives around the world and are prescribed for a very good reason for this, explained study author Christian Wolfrum from the Swiss Federal Institute of technology Zurich (ETH Zurich). Statins have no effect, however, only a negative effect on the brown fat tissue, you have at least one further negative effects: In high doses, increase the risk of developing Diabetes. (as)